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TC LPA5 4

CAS No. 1393814-38-4

TC LPA5 4( —— )

Catalog No. M33938 CAS No. 1393814-38-4

TC LPA5 4 is a LPA5 receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TC LPA5 4
  • Note
    Research use only, not for human use.
  • Brief Description
    TC LPA5 4 is a LPA5 receptor antagonist.
  • Description
    TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.
  • In Vitro
    ——
  • In Vivo
    Animal Model:BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) Dosage:10 mg/kg Administration:Intraperitoneal injection; 5 days/week for 2 weeks Result:Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    LPA Receptor
  • Recptor
    LPA Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1393814-38-4
  • Formula Weight
    410.89
  • Molecular Formula
    C23H23ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (152.11 mM; Ultrasonic )
  • SMILES
    C(O)(=O)C=1C=C(N(N1)C2=CC(OC)=CC=C2)C3=CC(Cl)=C(C=C3)C4CCCCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kozian DH, et al. Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg Med Chem Lett. 2012;22(16):5239-5243.?
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